Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer
Identifieur interne : 006F02 ( Main/Exploration ); précédent : 006F01; suivant : 006F03Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer
Auteurs : R J E. Skipworth [Royaume-Uni] ; D A C. Deans [Royaume-Uni] ; B H L. Tan [Royaume-Uni] ; K. Sangster [Royaume-Uni] ; S. Paterson-Brown [Royaume-Uni] ; D A Brown [Australie] ; M. Hunter [Australie] ; S N Breit [Australie] ; J A Ross [Royaume-Uni] ; K C H. Fearon [Royaume-Uni]Source :
- British Journal of Cancer [ 0007-0920 ] ; 2010.
Abstract
Macrophage inhibitory cytokine-1(MIC-1) is a potential modulator of systemic inflammation and nutritional depletion, both of which are adverse prognostic factors in oesophago-gastric cancer (OGC).
Plasma MIC-1, systemic inflammation (defined as plasma C-reactive protein (CRP) of ⩾10 mg l–1 or modified Glasgow prognostic score (mGPS) of ⩾1), and nutritional status were assessed in newly diagnosed OGC patients (
MIC-1 was elevated in patients (median=1371 pg ml–1; range 141–39 053) when compared with controls (median=377 pg ml–1; range 141–3786;
There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC.
Url:
DOI: 10.1038/sj.bjc.6605532
PubMed: 20104227
PubMed Central: 2837566
Affiliations:
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Deans</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tan, B H L" sort="Tan, B H L" uniqKey="Tan B" first="B H L" last="Tan">B H L. Tan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sangster, K" sort="Sangster, K" uniqKey="Sangster K" first="K" last="Sangster">K. 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Paterson-Brown</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brown, D A" sort="Brown, D A" uniqKey="Brown D" first="D A" last="Brown">D A Brown</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales</institution> Victoria Street, Sydney, New South Wales 2010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hunter, M" sort="Hunter, M" uniqKey="Hunter M" first="M" last="Hunter">M. 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Fearon</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20104227</idno><idno type="pmc">2837566</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837566</idno><idno type="RBID">PMC:2837566</idno><idno type="doi">10.1038/sj.bjc.6605532</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000025</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000025</idno><idno type="wicri:Area/Pmc/Curation">000025</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000025</idno><idno type="wicri:Area/Pmc/Checkpoint">002500</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002500</idno><idno type="wicri:Area/Ncbi/Merge">000711</idno><idno type="wicri:Area/Ncbi/Curation">000711</idno><idno type="wicri:Area/Ncbi/Checkpoint">000711</idno><idno type="wicri:doubleKey">0007-0920:2010:Skipworth R:plasma:mic:correlates</idno><idno type="wicri:Area/Main/Merge">007396</idno><idno type="wicri:Area/Main/Curation">006F02</idno><idno type="wicri:Area/Main/Exploration">006F02</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer</title><author><name sortKey="Skipworth, R J E" sort="Skipworth, R J E" uniqKey="Skipworth R" first="R J E" last="Skipworth">R J E. Skipworth</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deans, D A C" sort="Deans, D A C" uniqKey="Deans D" first="D A C" last="Deans">D A C. Deans</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tan, B H L" sort="Tan, B H L" uniqKey="Tan B" first="B H L" last="Tan">B H L. Tan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sangster, K" sort="Sangster, K" uniqKey="Sangster K" first="K" last="Sangster">K. Sangster</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Paterson Brown, S" sort="Paterson Brown, S" uniqKey="Paterson Brown S" first="S" last="Paterson-Brown">S. Paterson-Brown</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brown, D A" sort="Brown, D A" uniqKey="Brown D" first="D A" last="Brown">D A Brown</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales</institution> Victoria Street, Sydney, New South Wales 2010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hunter, M" sort="Hunter, M" uniqKey="Hunter M" first="M" last="Hunter">M. Hunter</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales</institution> Victoria Street, Sydney, New South Wales 2010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Breit, S N" sort="Breit, S N" uniqKey="Breit S" first="S N" last="Breit">S N Breit</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales</institution> Victoria Street, Sydney, New South Wales 2010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ross, J A" sort="Ross, J A" uniqKey="Ross J" first="J A" last="Ross">J A Ross</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fearon, K C H" sort="Fearon, K C H" uniqKey="Fearon K" first="K C H" last="Fearon">K C H. Fearon</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh</institution> 51 Little France Crescent, Edinburgh EH16 4SA,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Macrophage inhibitory cytokine-1(MIC-1) is a potential modulator of systemic inflammation and nutritional depletion, both of which are adverse prognostic factors in oesophago-gastric cancer (OGC).</p></sec><sec><title>Methods:</title><p>Plasma MIC-1, systemic inflammation (defined as plasma C-reactive protein (CRP) of ⩾10 mg l<sup>–1</sup> or modified Glasgow prognostic score (mGPS) of ⩾1), and nutritional status were assessed in newly diagnosed OGC patients (<italic>n</italic>=293). Healthy volunteers (<italic>n</italic>=35) served as controls.</p></sec><sec><title>Results:</title><p>MIC-1 was elevated in patients (median=1371 pg ml<sup>–1</sup>; range 141–39 053) when compared with controls (median=377 pg ml<sup>–1</sup>; range 141–3786; <italic>P</italic><0.001). Patients with gastric tumours (median=1592 pg ml<sup>–1</sup>; range 141–12 643) showed higher MIC-1 concentrations than patients with junctional (median=1337 pg ml<sup>–1</sup>; range 383–39 053) and oesophageal tumours (median=1180 pg ml<sup>–1</sup>; range 258–31 184; <italic>P</italic>=0.015). Patients showed a median weight loss of 6.4% (range 0.0–33.4%), and 42% of patients had an mGPS of ⩾1 or plasma CRP of ⩾10 mg l<sup>–1</sup> (median=9 mg l<sup>–1</sup>; range 1–200). MIC-1 correlated positively with disease stage (<italic>r</italic><sup>2</sup>=0.217; <italic>P</italic><0.001), age (<italic>r</italic><sup>2</sup>=0.332; <italic>P</italic><0.001), CRP (<italic>r</italic><sup>2</sup>=0.314; <italic>P</italic><0.001), and mGPS (<italic>r</italic><sup>2</sup>=0.336; <italic>P</italic><0.001), and negatively with Karnofsky Performance Score (<italic>r</italic><sup>2</sup>=−0.269; <italic>P</italic><0.001). However, although MIC-1 correlated weakly with dietary intake (r<sup>2</sup>=0.157; <italic>P</italic>=0.031), it did not correlate with weight loss, BMI, or anthropometry. Patients with MIC-1 levels in the upper quartile showed reduced survival (median=204 days; 95% CI 157–251) when compared with patients with MIC-1 levels in the lower three quartiles (median=316 days; 95% CI 259–373; <italic>P</italic>=0.036), but MIC-1 was not an independent prognostic indicator.</p></sec><sec><title>Conclusions:</title><p>There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Skipworth, R J E" sort="Skipworth, R J E" uniqKey="Skipworth R" first="R J E" last="Skipworth">R J E. Skipworth</name></noRegion><name sortKey="Deans, D A C" sort="Deans, D A C" uniqKey="Deans D" first="D A C" last="Deans">D A C. Deans</name><name sortKey="Fearon, K C H" sort="Fearon, K C H" uniqKey="Fearon K" first="K C H" last="Fearon">K C H. Fearon</name><name sortKey="Paterson Brown, S" sort="Paterson Brown, S" uniqKey="Paterson Brown S" first="S" last="Paterson-Brown">S. Paterson-Brown</name><name sortKey="Ross, J A" sort="Ross, J A" uniqKey="Ross J" first="J A" last="Ross">J A Ross</name><name sortKey="Sangster, K" sort="Sangster, K" uniqKey="Sangster K" first="K" last="Sangster">K. Sangster</name><name sortKey="Tan, B H L" sort="Tan, B H L" uniqKey="Tan B" first="B H L" last="Tan">B H L. Tan</name></country><country name="Australie"><noRegion><name sortKey="Brown, D A" sort="Brown, D A" uniqKey="Brown D" first="D A" last="Brown">D A Brown</name></noRegion><name sortKey="Breit, S N" sort="Breit, S N" uniqKey="Breit S" first="S N" last="Breit">S N Breit</name><name sortKey="Hunter, M" sort="Hunter, M" uniqKey="Hunter M" first="M" last="Hunter">M. Hunter</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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